Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis

Heart failure due to dilated cardiomyopathy is frequently caused by myocarditis. However, the pathogenesis of myocarditis remains incompletely understood. Here, we report the presence of neutrophil extracellular traps (NETs) in cardiac tissue of patients and mice with myocarditis. Inhibition of NET...

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Publicat a:J Exp Med
Autors principals: Weckbach, Ludwig T., Grabmaier, Ulrich, Uhl, Andreas, Gess, Sebastian, Boehm, Felicitas, Zehrer, Annette, Pick, Robert, Salvermoser, Melanie, Czermak, Thomas, Pircher, Joachim, Sorrelle, Noah, Migliorini, Mary, Strickland, Dudley K., Klingel, Karin, Brinkmann, Volker, Abu Abed, Ulrike, Eriksson, Urs, Massberg, Steffen, Brunner, Stefan, Walzog, Barbara
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363424/
https://ncbi.nlm.nih.gov/pubmed/30647120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181102
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