Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis

Heart failure due to dilated cardiomyopathy is frequently caused by myocarditis. However, the pathogenesis of myocarditis remains incompletely understood. Here, we report the presence of neutrophil extracellular traps (NETs) in cardiac tissue of patients and mice with myocarditis. Inhibition of NET...

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Pubblicato in:J Exp Med
Autori principali: Weckbach, Ludwig T., Grabmaier, Ulrich, Uhl, Andreas, Gess, Sebastian, Boehm, Felicitas, Zehrer, Annette, Pick, Robert, Salvermoser, Melanie, Czermak, Thomas, Pircher, Joachim, Sorrelle, Noah, Migliorini, Mary, Strickland, Dudley K., Klingel, Karin, Brinkmann, Volker, Abu Abed, Ulrike, Eriksson, Urs, Massberg, Steffen, Brunner, Stefan, Walzog, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2019
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363424/
https://ncbi.nlm.nih.gov/pubmed/30647120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181102
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