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Facilitation of I(Kr) current by some hERG channel blockers suppresses early afterdepolarizations
Drug-induced block of the cardiac rapid delayed rectifying potassium current (I(Kr)), carried by the human ether-a-go-go-related gene (hERG) channel, is the most common cause of acquired long QT syndrome. Indeed, some, but not all, drugs that block hERG channels cause fatal cardiac arrhythmias. Howe...
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| Publicado en: | J Gen Physiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363420/ https://ncbi.nlm.nih.gov/pubmed/30674563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812192 |
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