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Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response
During physical exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in protein kinase A (PKA)–mediated phosphorylation of the cardiac ryanodine receptor RyR2. PKA-dependent “hyperphosphorylation” of the RyR2 channel has b...
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| Publicado no: | J Gen Physiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363414/ https://ncbi.nlm.nih.gov/pubmed/30541771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812155 |
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