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IL-34–Dependent Intrarenal and Systemic Mechanisms Promote Lupus Nephritis in MRL-Fas(lpr) Mice
BACKGROUND: In people with SLE and in the MRL-Fas(lpr) lupus mouse model, macrophages and autoantibodies are central to lupus nephritis. IL-34 mediates macrophage survival and proliferation, is expressed by tubular epithelial cells (TECs), and binds to the cFMS receptor on macrophages and to a newly...
Tallennettuna:
| Julkaisussa: | J Am Soc Nephrol |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society of Nephrology
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6362618/ https://ncbi.nlm.nih.gov/pubmed/30622154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018090901 |
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