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Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization
In this study, we aimed to optimize theophylline pellet formulations using a two-factor three-level full-factorial design (3(2)) by monitoring the concentration of two pellet excipients, polyvinyl pyrrolidone K30 (PVP) binder solution (X1) and the hydrophilic excipient mannitol (X2). Their impact on...
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| Publicado no: | Saudi Pharm J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6362277/ https://ncbi.nlm.nih.gov/pubmed/30766428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsps.2018.10.002 |
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