Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections throughout the entire body that are capable of executing potent and immediate immunostimulatory functions. Here we show that virus-specific mem...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Rosato, Pamela C., Wijeyesinghe, Sathi, Stolley, J. Michael, Nelson, Christine E., Davis, Rachel L., Manlove, Luke S., Pennell, Christopher A., Blazar, Bruce R., Chen, Clark C., Geller, Melissa A., Vezys, Vaiva, Masopust, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362136/
https://ncbi.nlm.nih.gov/pubmed/30718505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08534-1
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