Unfolded protein response is an early, non-critical event during hepatic stellate cell activation

Hepatic stellate cells activate upon liver injury and help at restoring damaged tissue by producing extracellular matrix proteins. A drastic increase in matrix proteins results in liver fibrosis and we hypothesize that this sudden increase leads to accumulation of proteins in the endoplasmic reticul...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Mannaerts, Inge, Thoen, Lien F. R., Eysackers, Nathalie, Cubero, Francisco Javier, Batista Leite, Sofia, Coldham, Iain, Colle, Isabelle, Trautwein, Christian, van Grunsven, Leo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362073/
https://ncbi.nlm.nih.gov/pubmed/30718473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1327-5
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