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3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish
3-ketodihydrosphingosine reductase (KDSR) is the key enzyme in the de novo sphingolipid synthesis. We identified a novel missense kdsr(I105R) mutation in zebrafish that led to a loss of function, and resulted in progression of hepatomegaly to steatosis, then hepatic injury phenotype. Lipidomics anal...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6361991/ https://ncbi.nlm.nih.gov/pubmed/30718751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37946-0 |
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