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Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes

Preclinical studies point to a pivotal role of the orexin 1 (OX(1)) receptor in arousal and fear learning and therefore suggest the HCRTR1 gene as a prime candidate in panic disorder (PD) with/without agoraphobia (AG), PD/AG treatment response, and PD/AG-related intermediate phenotypes. Here, a mult...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: Gottschalk, Michael G., Richter, Jan, Ziegler, Christiane, Schiele, Miriam A., Mann, Julia, Geiger, Maximilian J., Schartner, Christoph, Homola, György A., Alpers, Georg W., Büchel, Christian, Fehm, Lydia, Fydrich, Thomas, Gerlach, Alexander L., Gloster, Andrew T., Helbig-Lang, Sylvia, Kalisch, Raffael, Kircher, Tilo, Lang, Thomas, Lonsdorf, Tina B., Pané-Farré, Christiane A., Ströhle, Andreas, Weber, Heike, Zwanzger, Peter, Arolt, Volker, Romanos, Marcel, Wittchen, Hans-Ulrich, Hamm, Alfons, Pauli, Paul, Reif, Andreas, Deckert, Jürgen, Neufang, Susanne, Höfler, Michael, Domschke, Katharina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361931/
https://ncbi.nlm.nih.gov/pubmed/30718541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-019-0415-8
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