Peripheral Inflammation Regulates CNS Immune Surveillance Through the Recruitment of Inflammatory Monocytes Upon Systemic α-Synuclein Administration

Innate immune activation and chronic neuroinflammation are characteristic features of many neurodegenerative diseases including Parkinson's disease (PD) and may contribute to the pathophysiology of the disease. The discovery of misfolded alpha-synuclein (αSYN) protein aggregates, which amplify...

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Publicado en:Front Immunol
Autores principales: Peralta Ramos, Javier María, Iribarren, Pablo, Bousset, Luc, Melki, Ronald, Baekelandt, Veerle, Van der Perren, Anke
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361759/
https://ncbi.nlm.nih.gov/pubmed/30761145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00080
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