Anti‐tumor effects of mAb against l‐type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes

l‐Type amino acid transporter 1 (LAT1) disulfide linked to CD98 heavy chain (hc) is highly expressed in most cancer cells, but weakly expressed in normal cells. In the present study, we developed novel anti‐LAT1 mAbs and showed internalization activity, inhibitory effects of amino acid uptake and ce...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Ueda, Shiho, Hayashi, Hidemi, Miyamoto, Takako, Abe, Shinya, Hirai, Kana, Matsukura, Kanji, Yagi, Hideki, Hara, Yuta, Yoshida, Kinji, Okazaki, Shogo, Tamura, Masakazu, Abe, Yuki, Agatsuma, Toshinori, Niwa, Shin‐ichiro, Masuko, Kazue, Masuko, Takashi
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361610/
https://ncbi.nlm.nih.gov/pubmed/30548114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13908
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