Anti‐tumor effects of mAb against l‐type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes

l‐Type amino acid transporter 1 (LAT1) disulfide linked to CD98 heavy chain (hc) is highly expressed in most cancer cells, but weakly expressed in normal cells. In the present study, we developed novel anti‐LAT1 mAbs and showed internalization activity, inhibitory effects of amino acid uptake and ce...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Ueda, Shiho, Hayashi, Hidemi, Miyamoto, Takako, Abe, Shinya, Hirai, Kana, Matsukura, Kanji, Yagi, Hideki, Hara, Yuta, Yoshida, Kinji, Okazaki, Shogo, Tamura, Masakazu, Abe, Yuki, Agatsuma, Toshinori, Niwa, Shin‐ichiro, Masuko, Kazue, Masuko, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361610/
https://ncbi.nlm.nih.gov/pubmed/30548114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13908
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