Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target

L-type amino acid transporter 1 (LAT1)/SLC7A5 is the first identified CD98 light chain disulfide linked to the CD98 heavy chain (CD98hc/SLC3A2). LAT1 transports large neutral amino acids, including leucine, which activates mTOR, and is highly expressed in human cancers. We investigated the oncogenic...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Hayashi, Natsumi, Yamasaki, Akitaka, Ueda, Shiho, Okazaki, Shogo, Ohno, Yoshiya, Tanaka, Toshiyuki, Endo, Yuichi, Tomioka, Yoshihisa, Masuko, Kazue, Masuko, Takashi, Sugiura, Reiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2021
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8238248/
https://ncbi.nlm.nih.gov/pubmed/34194623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27981
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