Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells

PURPOSE: To characterize two mitochondrial membrane transporters 2-oxoglutarate (OGC) and dicarboxylate (DIC) in human RPE (hRPE) and to elucidate their role in the regulation of mitochondrial glutathione (mGSH) uptake and cell death in oxidative stress. METHODS: The localization of OGC and DIC prot...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Wang, Mo, Lau, Lin-Ing, Sreekumar, Parameswaran G., Spee, Christine, Hinton, David R., Sadda, Srinivas R., Kannan, Ram
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2019
Témata:
Retinal Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360990/
https://ncbi.nlm.nih.gov/pubmed/30707752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.18-25686
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