Modulating CRISPR gene drive activity through nucleocytoplasmic localization of Cas9 in S. cerevisiae

BACKGROUND: The bacterial CRISPR/Cas genome editing system has provided a major breakthrough in molecular biology. One use of this technology is within a nuclease-based gene drive. This type of system can install a genetic element within a population at unnatural rates. Combatting of vector-borne di...

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Publicat a:Fungal Biol Biotechnol
Autors principals: Goeckel, Megan E., Basgall, Erianna M., Lewis, Isabel C., Goetting, Samantha C., Yan, Yao, Halloran, Megan, Finnigan, Gregory C.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360766/
https://ncbi.nlm.nih.gov/pubmed/30766726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40694-019-0065-x
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