PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27(Kip1) axis

BACKGROUND: Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated in hepatocellular carcinoma (HCC) and predicts poor prognosis. Overexpression...

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Gepubliceerd in:J Exp Clin Cancer Res
Hoofdauteurs: Tuo, Lin, Xiang, Jin, Pan, Xuanming, Hu, Jieli, Tang, Hua, Liang, Li, Xia, Jie, Hu, Yuan, Zhang, Wenlu, Huang, Ailong, Wang, Kai, Tang, Ni
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360696/
https://ncbi.nlm.nih.gov/pubmed/30717766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1029-y
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