Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia

BACKGROUND: Aurothioglucose- (ATG-) mediated inhibition of thioredoxin reductase-1 (TXNRD1) improves alveolarization in experimental murine bronchopulmonary dysplasia (BPD). Glutathione (GSH) mediates susceptibility to neonatal and adult oxidative lung injury. We have previously shown that ATG atten...

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Udgivet i:Oxid Med Cell Longev
Main Authors: Wall, Stephanie B., Wood, Rachael, Dunigan, Katelyn, Li, Qian, Li, Rui, Rogers, Lynette K., Tipple, Trent E.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360549/
https://ncbi.nlm.nih.gov/pubmed/30805084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/7945983
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