Targeting HER2 in patient‐derived xenograft ovarian cancer models sensitizes tumors to chemotherapy

Ovarian cancer is the most lethal gynecologic malignancy. About 75% of ovarian cancer patients relapse and/or develop chemo‐resistant disease after initial response to standard‐of‐care treatment with platinum‐based therapies. HER2 amplifications and overexpression in ovarian cancer are reported to v...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Harris, Faye R., Zhang, Piyan, Yang, Lin, Hou, Xiaonan, Leventakos, Konstantinos, Weroha, Saravut J., Vasmatzis, George, Kovtun, Irina V.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360362/
https://ncbi.nlm.nih.gov/pubmed/30499260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12414
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