Viral Infection or IFN-α Alters Mitotic Spindle Orientation by Modulating Pericentrin Levels

Congenital microcephaly occurs in utero during Zika virus (ZIKV) infection. The single-gene disorder, Majewski osteodysplastic primordial dwarfism type II (MOPDII), also leads to microcephaly and is concomitant with a decrease in the centrosomal protein, pericentrin (PCNT). This protein is a known c...

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Publicado en:iScience
Main Authors: McDougall, William M., Perreira, Jill M., Hung, Hui-Fang, Vertii, Anastassiia, Xiaofei, E., Zimmerman, Wendy, Kowalik, Timothy F., Doxsey, Stephen, Brass, Abraham L.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360249/
https://ncbi.nlm.nih.gov/pubmed/30716700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.01.025
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