Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

A series of simple C-alkyl pyrrolidines already known as cytotoxic inhibitors of ceramide glucosylation in melanoma cells can be converted into their corresponding 6-membered analogues by means of a simple ring expansion. This study illustrated how an isomerisation from iminosugar pyrrolidine toward...

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Veröffentlicht in:Molecules
Hauptverfasser: Baudoin-Dehoux, Cécile, Castellan, Tessa, Rodriguez, Frédéric, Rives, Arnaud, Stauffert, Fabien, Garcia, Virginie, Levade, Thierry, Compain, Philippe, Génisson, Yves
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359432/
https://ncbi.nlm.nih.gov/pubmed/30669468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24020354
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