Efficient Selection of Antibodies Reactive to Homologous Epitopes on Human and Mouse Hepatocyte Growth Factors by Next-Generation Sequencing-Based Analysis of the B Cell Repertoire

YYB-101 is a humanized rabbit anti-human hepatocyte growth factor (HGF)-neutralizing antibody currently in clinical trial. To test the effect of HGF neutralization with antibody on anti-cancer T cell immunity, we generated surrogate antibodies that are reactive to the mouse homologue of the epitope...

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Foilsithe in:Int J Mol Sci
Main Authors: Kim, Soohyun, Lee, Hyunho, Noh, Jinsung, Lee, Yonghee, Han, Haejun, Yoo, Duck Kyun, Kim, Hyori, Kwon, Sunghoon, Chung, Junho
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2019
Ábhair:
Communication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359367/
https://ncbi.nlm.nih.gov/pubmed/30669409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20020417
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