Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells

The aims of this study were to determine whether combination chemotherapeutics exhibit a synergistic effect on breast cancer cell metabolism. Palbociclib, is a selective inhibitor of cyclin-dependent kinases 4 and 6, and when patients are treated in combination with fulvestrant, an estrogen receptor...

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Udgivet i:Metabolites
Main Authors: Warth, Benedikt, Palermo, Amelia, Rattray, Nicholas J.W., Lee, Nathan V., Zhu, Zhou, Hoang, Linh T., Cai, Yuping, Mazurek, Anthony, Dann, Stephen, VanArsdale, Todd, Fantin, Valeria R., Shields, David, Siuzdak, Gary, Johnson, Caroline H.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359333/
https://ncbi.nlm.nih.gov/pubmed/30609717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo9010007
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