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Metabolomics Reveals that Dietary Xenoestrogens Alter Cellular Metabolism Induced by Palbociclib/Letrozole Combination Cancer Therapy

Recently, the palbociclib/letrozole combination therapy was granted accelerated US FDA approval for the treatment of estrogen receptor (ER)-positive breast cancer. Since the underlying metabolic effects of these drugs are yet unknown, we investigated their synergism at the metabolome level in MCF-7...

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Publicado en:Cell Chem Biol
Autores principales: Warth, Benedikt, Raffeiner, Philipp, Granados, Ana, Huan, Tao, Fang, Mingliang, Forsberg, Erica M., Benton, H. Paul, Goetz, Laura, Johnson, Caroline H., Siuzdak, Gary
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856613/
https://ncbi.nlm.nih.gov/pubmed/29337187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.12.010
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