A New Approach for Improving the Antibacterial and Tumor Cytotoxic Activities of Pipemidic Acid by Including It in Trimethyl-β-cyclodextrin

Pipemidic acid (HPPA) is a quinolone antibacterial agent used mostly to treat gram-negative infections of the urinary tract, but its therapeutic use is limited because of its low solubility. Thus, to improve drug solubility, natural cyclodextrins (CDs) are used for their ability of including guest m...

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Pubblicato in:Int J Mol Sci
Autori principali: Lavorgna, Margherita, Iacovino, Rosa, Russo, Chiara, Di Donato, Cristina, Piscitelli, Concetta, Isidori, Marina
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359225/
https://ncbi.nlm.nih.gov/pubmed/30669399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20020416
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