Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State

Beta-2 microglobulin (β2m) is a protein responsible for a pathologic condition, known as dialysis-related amyloidosis (DRA), caused by its aggregation and subsequent amyloid formation. A naturally occurring mutation of β2m, D76N, presents a higher amyloidogenic propensity compared to the wild type c...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Visconti, Lorenzo, Malagrinò, Francesca, Broggini, Luca, De Luca, Chiara Maria Giulia, Moda, Fabio, Gianni, Stefano, Ricagno, Stefano, Toto, Angelo
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6359115/
https://ncbi.nlm.nih.gov/pubmed/30669253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20020396
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