Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing

OBJECTIVE: Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as shown by invalidation of the hypothalamic DRP1 protein...

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Publicado en:Mol Metab
Autores principales: Desmoulins, Lucie, Chrétien, Chloé, Paccoud, Romain, Collins, Stephan, Cruciani-Guglielmacci, Céline, Galinier, Anne, Liénard, Fabienne, Quinault, Aurore, Grall, Sylvie, Allard, Camille, Fenech, Claire, Carneiro, Lionel, Mouillot, Thomas, Fournel, Audren, Knauf, Claude, Magnan, Christophe, Fioramonti, Xavier, Pénicaud, Luc, Leloup, Corinne
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2018
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358535/
https://ncbi.nlm.nih.gov/pubmed/30553770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.11.007
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