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Mitochondrial polymorphisms contribute to aging phenotypes in MNX mouse models

Many inbred strains of mice develop spontaneous tumors as they age. Recent awareness of the impacts of mitochondrial DNA (mtDNA) on cancer and aging have inspired developing a Mitochondrial-Nuclear Exchange (MNX) mouse model in which nuclear DNA is paired with mitochondrial genomes from other strain...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Metastasis Rev
Prif Awduron: Vivian, Carolyn J., Hagedorn, Travis M., Jensen, Roy A., Brinker, Amanda E., Welch, Danny R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358467/
https://ncbi.nlm.nih.gov/pubmed/30547266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10555-018-9773-6
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