Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity

Myelodysplastic syndromes (MDSs) are stem cell disorders with risk of transformation to acute myeloid leukemia (AML). Gene expression profiling reveals transcriptional expression of GLI1, of Hedgehog (Hh) signaling, in poor-risk MDS/AML. Using a murine model of MDS we demonstrated that constitutive...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Lau, Bonnie W., Huh, Kyounghee, Madero-Marroquin, Rafael, Marchi, Federico De, Lim, Yiting, Wang, Qiuju, Lobo, Francisco, Marchionni, Luigi, Smith, Douglas B., DeZern, Amy, Levis, Mark J., Aplan, Peter D., Matsui, William, Gondek, Lukasz P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358463/
https://ncbi.nlm.nih.gov/pubmed/30171262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0431-9
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