Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia

FLT3 internal tandem duplication (ITD) mutations resulting in constitutive kinase activity are common in acute myeloid leukemia (AML) and carry a poor prognosis. Several agents targeting FLT3 have been developed, but their limited clinical activity suggests that the inhibition of other factors contr...

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Publicat a:Sci Transl Med
Autors principals: Lim, Yiting, Gondek, Lukasz, Li, Li, Wang, Qiuju, Ma, Haley, Chang, Emily, Huso, David L., Foerster, Sarah, Marchionni, Luigi, McGovern, Karen, Watkins, D. Neil, Peacock, Craig D., Levis, Mark, Smith, B. Douglas, Merchant, Akil A., Small, Donald, Matsui, William
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4644635/
https://ncbi.nlm.nih.gov/pubmed/26062848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa5731
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