Ganetespib, an HSP90 inhibitor, kills Epstein-Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood

HSP90 inhibitors have been shown to kill Epstein-Barr virus (EBV)-infected cells by reducing the level of EBV EBNA-1 and/or LMP1. We treated virus-infected cells with ganetespib, an HSP90 inhibitor currently being evaluated in multiple clinical trials for cancer, and found that the drug killed EBV-p...

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I publikationen:Leuk Lymphoma
Huvudupphovsmän: Shatzer, Amber, Ali, Mir A., Chavez, Mayra, Dowdell, Kennichi, Lee, Min-Jung, Tomita, Yusuke, El-Hariry, Iman, Trepel, Jane B., Proia, David A., Cohen, Jeffrey I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358278/
https://ncbi.nlm.nih.gov/pubmed/27686857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2016.1213823
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