Controlling the dynamics of the Nek2 leucine zipper by engineering of “kinetic” disulphide bonds

Nek2 is a dimeric serine/ threonine protein kinase that belongs to the family of NIMA-related kinases (Neks). Its N-terminal catalytic domain and its C-terminal regulatory region are bridged by a leucine zipper, which plays an important role in the activation of Nek2’s catalytic activity. Unusual co...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Gutmans, Daniel S., Whittaker, Sara B-M, Asiani, Karishma, Atkinson, R. Andrew, Oregioni, Alain, Pfuhl, Mark
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358272/
https://ncbi.nlm.nih.gov/pubmed/30707691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0210352
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items