Relative Frequencies of Alloantigen-Specific Helper CD4 T Cells and B Cells Determine Mode of Antibody-Mediated Allograft Rejection

Humoral alloimmunity is now recognized as a major determinant of transplant outcome. MHC glycoprotein is considered a typical T-dependent antigen, but the nature of the T cell alloresponse that underpins alloantibody generation remains poorly understood. Here, we examine how the relative frequencies...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Alsughayyir, Jawaher, Chhabra, Manu, Qureshi, M. Saeed, Mallik, Mekhola, Ali, Jason M., Gamper, Ivonne, Moseley, Ellen L., Peacock, Sarah, Kosmoliaptsis, Vasilis, Goddard, Martin J., Linterman, Michelle A., Motallebzadeh, Reza, Pettigrew, Gavin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357941/
https://ncbi.nlm.nih.gov/pubmed/30740108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03039
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