CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection

Adaptive CD8 T-cell immunity is the principal arm of the cellular alloimmune response, but its development requires help. This can be provided by CD4 T cells that recognize alloantigen “indirectly,” as self-restricted allopeptide, but this process remains unexplained, because the target epitopes for...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Harper, Simon J. F., Ali, Jason M., Wlodek, Elizabeth, Negus, Marg C., Harper, Ines G., Chhabra, Manu, Qureshi, M. Saeed, Mallik, Mekhola, Bolton, Eleanor, Bradley, J. Andrew, Pettigrew, Gavin J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611606/
https://ncbi.nlm.nih.gov/pubmed/26420874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513533112
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