Neutrophil α-defensins promote thrombosis in vivo by altering fibrin formation, structure, and stability

Inflammation and thrombosis are integrated, mutually reinforcing processes, but the interregulatory mechanisms are incompletely defined. Here, we examined the contribution of α-defensins (α-defs), antimicrobial proteins released from activated human neutrophils, on clot formation in vitro and in viv...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Abu-Fanne, Rami, Stepanova, Victoria, Litvinov, Rustem I., Abdeen, Suhair, Bdeir, Khalil, Higazi, Mohamed, Maraga, Emad, Nagaswami, Chandrasekaran, Mukhitov, Alexander R., Weisel, John W., Cines, Douglas B., Higazi, Abd Al-Roof
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356988/
https://ncbi.nlm.nih.gov/pubmed/30442678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-07-861237
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