Constitutive BRCA1 Promoter Hypermethylation Can Be a Predisposing Event in Isolated Early-Onset Breast Cancer

Early age at onset of breast cancer (eoBC) is suggestive of an increased genetic risk. Although genetic testing is offered to all eoBC-affected women, in isolated cases the detection rate of pathogenic variants is <10%. This study aimed at assessing the role of constitutive promoter methylation a...

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發表在:Cancers (Basel)
Main Authors: Azzollini, Jacopo, Pesenti, Chiara, Pizzamiglio, Sara, Fontana, Laura, Guarino, Carmela, Peissel, Bernard, Plebani, Maddalena, Tabano, Silvia, Sirchia, Silvia Maria, Colapietro, Patrizia, Villa, Roberta, Paolini, Biagio, Verderio, Paolo, Miozzo, Monica, Manoukian, Siranoush
格式: Artigo
語言:Inglês
出版: MDPI 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356733/
https://ncbi.nlm.nih.gov/pubmed/30634417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11010058
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