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Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression

Pancreatic cancer is poorly responsive to chemotherapy due to intrinsic or acquired resistance. Our previous study showed that epigenetic modifying enzymes including protein arginine methyltransferase 3 (PRMT3) are dysregulated in gemcitabine (GEM)-resistant pancreatic cancer cells. Here, we attempt...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Hsu, Ming-Chuan, Pan, Mei-Ren, Chu, Pei-Yi, Tsai, Ya-Li, Tsai, Chia-Hua, Shan, Yan-Shen, Chen, Li-Tzong, Hung, Wen-Chun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356582/
https://ncbi.nlm.nih.gov/pubmed/30577570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11010008
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