KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced S-Glutathionylation of Distinct Structural and Regulatory Proteins

Loss-of-function mutations in the KRIT1 gene are associated with the pathogenesis of cerebral cavernous malformations (CCMs), a major cerebrovascular disease still awaiting therapies. Accumulating evidence demonstrates that KRIT1 plays an important role in major redox-sensitive mechanisms, including...

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Veröffentlicht in:Antioxidants (Basel)
Hauptverfasser: Cianfruglia, Laura, Perrelli, Andrea, Fornelli, Claudia, Magini, Alessandro, Gorbi, Stefania, Salzano, Anna Maria, Antognelli, Cinzia, Retta, Francesca, Benedetti, Valerio, Cassoni, Paola, Emiliani, Carla, Principato, Giovanni, Scaloni, Andrea, Armeni, Tatiana, Retta, Saverio Francesco
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6356485/
https://ncbi.nlm.nih.gov/pubmed/30658464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox8010027
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