Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation

Regulatory T cells (Tregs) play a pivotal role in immune-tolerance, and loss of Treg function can lead to the development of autoimmunity. Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery, where they suppress self-reactive effector T cells (Teff) respo...

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Publicado en:Cell Mol Immunol
Main Authors: Kumar, Prabhakaran, Marinelarena, Alejandra, Raghunathan, Divya, Ragothaman, Vandhana K, Saini, Shikha, Bhattacharya, Palash, Fan, Jilao, Epstein, Alan L, Maker, Ajay V, Prabhakar, Bellur S
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355936/
https://ncbi.nlm.nih.gov/pubmed/29578532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2018.8
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