Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling

Regulatory T-cells (Tregs) play a pivotal role in maintaining peripheral tolerance. Increasing Treg numbers/functions has been shown to ameliorate autoimmune diseases. However, common Treg expansion approaches use T-Cell Receptor (TCR)-mediated stimulation which also causes proliferation of effector...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kumar, Prabhakaran, Alharshawi, Khaled, Bhattacharya, Palash, Marinelarena, Alejandra, Haddad, Christine, Sun, Zuoming, Chiba, Shigeru, Epstein, Alan L., Prabhakar, Bellur S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206631/
https://ncbi.nlm.nih.gov/pubmed/28045060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39751
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