Chronic fluoxetine prevents fear memory generalization and enhances subsequent extinction by remodeling hippocampal dendritic spines and slowing down systems consolidation

Fear memory overgeneralization contributes to the genesis and persistence of anxiety disorders and is a central hallmark in the pathophysiology of post-traumatic stress disorder (PTSD). Recent findings suggest that fear generalization is closely related to hippocampal dependency during retrieval. Th...

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Publicado en:Transl Psychiatry
Autores principales: Pedraza, Lizeth K., Sierra, Rodrigo O., Giachero, Marcelo, Nunes-Souza, Walquiria, Lotz, Fernanda N., de Oliveira Alvares, Lucas
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355903/
https://ncbi.nlm.nih.gov/pubmed/30705259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-019-0371-3
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