Clostridium perfringens α-toxin impairs granulocyte colony-stimulating factor receptor-mediated granulocyte production while triggering septic shock

During bacterial infection, granulocyte colony-stimulating factor (G-CSF) is produced and accelerates neutrophil production from their progenitors. This process, termed granulopoiesis, strengthens host defense, but Clostridium perfringens α-toxin impairs granulopoiesis via an unknown mechanism. Here...

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Udgivet i:Commun Biol
Main Authors: Takehara, Masaya, Seike, Soshi, Sonobe, Yuuta, Bandou, Hiroto, Yokoyama, Saki, Takagishi, Teruhisa, Miyamoto, Kazuaki, Kobayashi, Keiko, Nagahama, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355902/
https://ncbi.nlm.nih.gov/pubmed/30729183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0280-2
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