Induced in vivo knockdown of the Brca1 gene in skeletal muscle results in skeletal muscle weakness

KEY POINTS: Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function. BRCA1/Brca1 has recently been found to regulate several cellular pathways beyond DNA repair and is...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Tarpey, Michael D., Valencia, Ana P., Jackson, Kathryn C., Amorese, Adam J., Balestrieri, Nicholas P., Renegar, Randall H., Pratt, Stephen J. P., Ryan, Terence E., McClung, Joseph M., Lovering, Richard M., Spangenburg, Espen E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Muscle
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355718/
https://ncbi.nlm.nih.gov/pubmed/30556208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276863
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