High-Dose Rifamycins Enable Shorter Oral Treatment in a Murine Model of Mycobacterium ulcerans Disease

Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical skin and soft tissue infection that is associated with disability and social stigma. The mainstay of BU treatment is an 8-week course of rifampin (RIF) at 10 mg/kg of body weight and 150 mg/kg streptomycin (STR). Recently,...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Omansen, Till F., Almeida, Deepak, Converse, Paul J., Li, Si-Yang, Lee, Jin, Stienstra, Ymkje, van der Werf, Tjip, Grosset, Jacques H., Nuermberger, Eric L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355596/
https://ncbi.nlm.nih.gov/pubmed/30455239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01478-18
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