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Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?
Therapeutic factor VIII is highly immunogenic. Despite intensive research in the last decades, the reasons why 5-30% of patients with hemophilia A (of all severities) develop inhibitory anti-factor VIII antibodies (inhibitors) following replacement therapy remain an enigma. Under physiological condi...
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| Publicado no: | Haematologica |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Ferrata Storti Foundation
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355482/ https://ncbi.nlm.nih.gov/pubmed/30514798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.206383 |
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