Chemical chaperone 4-phenylbutyrate prevents hearing loss and cochlear hair cell death in Cdh23(erl/erl) mutant mice

We previously developed Cdh23(erl/erl) mutant mice (erl mice) as a model of hearing loss for otoprotective drug evaluation and showed that the erl mutation leads to hearing loss related to endoplasmic reticulum (ER) stress-induced cochlear hair cell apoptosis. Small molecular chemical chaperones, 4-...

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Foilsithe in:Neuroreport
Main Authors: Li, Bo, Zheng, Tihua, Yan, Caifang, Wang, Wenjun, Zhang, Jinjin, Zhang, Luping, Hu, Juan, Zhang, Li, Wan, Yuzhu, Zhang, Minyan, Zheng, Qingyin
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355346/
https://ncbi.nlm.nih.gov/pubmed/30516593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0000000000001173
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