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PTEN-opathies: from biological insights to evidence-based precision medicine
The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN hamartoma tumor syndrome (PHTS), featuring various benign and malignant tumors, as well as neurodevelopmental disorders such as autism...
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| Yayımlandı: | J Clin Invest |
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| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2019
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6355220/ https://ncbi.nlm.nih.gov/pubmed/30614812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121277 |
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