Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor (IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2012) for cholangiocarcinoma (CCA) in the Lower Mekong River Basin countries including Thailand, Lao PDR, Vietnam and Cambodia. We expl...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Arunsan, Patpicha, Ittiprasert, Wannaporn, Smout, Michael J, Cochran, Christina J, Mann, Victoria H, Chaiyadet, Sujittra, Karinshak, Shannon E, Sripa, Banchob, Young, Neil David, Sotillo, Javier, Loukas, Alex, Brindley, Paul J, Laha, Thewarach
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355195/
https://ncbi.nlm.nih.gov/pubmed/30644359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41463
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