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Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor (IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2012) for cholangiocarcinoma (CCA) in the Lower Mekong River Basin countries including Thailand, Lao PDR, Vietnam and Cambodia. We expl...

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Publicado en:eLife
Main Authors: Arunsan, Patpicha, Ittiprasert, Wannaporn, Smout, Michael J, Cochran, Christina J, Mann, Victoria H, Chaiyadet, Sujittra, Karinshak, Shannon E, Sripa, Banchob, Young, Neil David, Sotillo, Javier, Loukas, Alex, Brindley, Paul J, Laha, Thewarach
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355195/
https://ncbi.nlm.nih.gov/pubmed/30644359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41463
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