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Residual cyclooxygenase activity of aspirin-acetylated COX-2 forms 15R-prostaglandins that inhibit platelet aggregation

Aspirin (acetylsalicylic acid) inhibits prostaglandin (PG) synthesis by transfer of its acetyl group to a serine residue in the cyclooxygenase (COX) active site. Acetylation of Ser530 inhibits catalysis by preventing access of arachidonic acid substrate in the COX-1 isoenzyme. Acetylated COX-2, in c...

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Библиографические подробности
Опубликовано в: :FASEB J
Главные авторы: Giménez-Bastida, Juan A., Boeglin, William E., Boutaud, Olivier, Malkowski, Michael G., Schneider, Claus
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355089/
https://ncbi.nlm.nih.gov/pubmed/30096040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801018R
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