NKG2A blockade potentiates CD8 T-cell immunity induced by cancer vaccines

Tumor-infiltrating CD8 T cells were found to frequently express the inhibitory receptor NKG2A, particularly in immune-reactive environments and after therapeutic cancer vaccination. High dimensional cluster analysis demonstrated that NKG2A marks a unique immune effector subset preferentially co-expr...

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Publicat a:Cell
Autors principals: van Montfoort, Nadine, Borst, Linda, Korrer, Michael J., Sluijter, Marjolein, Marijt, Koen A., Santegoets, Saskia J., van Ham, Vanessa J., Ehsan, Ilina, Charoentong, Pornpimol, André, Pascale, Wagtmann, Nicolai, Welters, Marij J.P., Kim, Young J., Piersma, Sytse J., van der Burg, Sjoerd H., van Hall, Thorbald
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354585/
https://ncbi.nlm.nih.gov/pubmed/30503208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.028
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